Hungary Chapter

Hungarian Chapter (Hepato-Pancreatico-Biliary (HPB) Surgical Research Center Hungary) “Hepato-Pancreatico-Biliary (HPB) Surgical Research Center of Hungary” is a honored part of the Hungarian Surgical Association and includes about 40 members. HPB surgery is performed at 4 university clinics and some countryside hospital (the number is increasing progressively) in our country. In addition, Hungary is the member of Eurotransplant program, with more than 80 liver transplant yearly. Hepato-Pancreatico-Biliary (HPB) Surgical Research Center Hungary was established in 2015 by Professor Attila Szijarto (see link)

The aim of the association is to promote and coordinate clinical researches and educational program among HPB surgeon in Hungary. Since 2015, several regional and international conferences were organized by the working groups, including the “11th European Digestive Surgery Postgraduate Course” (2017), the “Complex treatment of colorectal liver metastases – consensus conference” (2019) and the “Complex treatment of Hepatocellular Carcinoma – consensus conference” (2021).

In addition, the working group has a significant activity in translational and clinical research as well, focusing especially on liver and pancreas surgery (ischemia and reperfusion, liver regeneration, liver transplantation), some example which is related to the board of the HPB Surgical Research Center of Hungary:

1. Szijártó A, Fülöp A.: Triggered liver regeneration: from experimental model to clinical implications. Eur Surg Res. 2015;54(3-4):148-61.
2. Czigány Z, Iwasaki J, Yagi S, Nagai K, Szijártó A, Uemoto S, Tolba RH.: Improving Research Practice in Rat Orthotopic and Partial Orthotopic Liver Transplantation: A Review, Recommendation, and Publication Guide. Eur Surg Res. 2015;55(1-2):119-38.
3. Fülöp A, Budai A, Czigány Z, Lotz G, Dezső K, Paku S, Harsányi L, Szijártó A.: Alterations in hepatic lobar function in regenerating rat liver. J Surg Res. 2015;197(2):307-17.
4. Czigány Z, Turóczi Z, Kleiner D, Lotz G, Homeyer A, Harsányi L, Szijártó A.: Neural elements behind the hepatoprotection of remote perconditioning. J Surg Res. 2015 Feb;193(2):642-51. 5. Lauber DT, Tihanyi DK, Czigány Z, Kovács T, Budai A, Drozgyik D, Fülöp A, Szijártó A.: Liver regeneration after different degrees of portal vein ligation. J Surg Res. 2016;203(2):451-8.
5. Kovács T, Máthé D, Fülöp A, Jemnitz K, Bátai-Konczos A, Veres Z, Török G, Veres DS, Horváth I, Szigeti K, Homolya L, Szijártó A.: Functional shift with maintained regenerative potential following portal vein ligation. Sci Rep. 2017;7(1):18065.
6. Budai A, Fulop A, Hahn O, Onody P, Kovacs T, Nemeth T, Dunay M, Szijarto A.: Animal Models for Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Achievements and Future Perspectives. Eur Surg Res. 2017;58(3-4):140-157.
7. Kovács T, Déri M, Fülöp A, Pálházy T, Háfra E, Sirok D, Kiss ÁF, Lotz G, Szijártó A, Monostory K.: Isoform-Dependent Changes in Cytochrome P450-Mediated Drug Metabolism after Portal Vein Ligation in the Rat. Eur Surg Res. 2018;59(5-6):301-319.
8. Czigany Z, Bleilevens C, Beckers C, Stoppe C, Möhring M, Fülöp A, Szijarto A, Lurje G, Neumann UP, Tolba RH.: Limb remote ischemic conditioning of the recipient protects the liver in a rat model of arterialized orthotopic liver transplantation. PLoS One. 2018 Apr 4;13(4):e0195507.
9. Budai A, Horváth G, Tretter L, Radák Z, Koltai E, Bori Z, Torma F, Lukáts Á, Röhlich P, Szijártó A, Fülöp A.: Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model. Br J Surg. 2019;106(1):120-131.
10. Tihanyi DK, Szijarto A, Fülöp A, Denecke B, Lurje G, Neumann UP, Czigany Z, Tolba R.: Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines. J Surg Res. 2019;235:578-590.
11. Hahn O, Bárdos D, Kupcsulik P, Szijártó A, Fülöp A, Kokas B, Pekli D, Zsirka-Klein A, Dudás I, Pajor P, Harsányi L.: [Decreasing morbidity after Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) with technical modification and patient selection]. Orv Hetil. 2019 Aug;160(32):1260-1269.
12. Huszár O, Szijarto A, Tihanyi T, Harsányi L, Szücs Á.: A novel percutaneous transhepatic treatment of a benign bile duct stricture - a pilot study. Croat Med J. 2019 Oct 31;60(5):397-404. 14. Zeöld A, Sándor GO, Kiss A, Soós AÁ, Tölgyes T, Bursics A, Szűcs Á, Harsányi L, Kittel Á, Gézsi A, Buzás EI, Wiener Z.: Shared extracellular vesicle miRNA profiles of matched ductal pancreatic adenocarcinoma organoids and blood plasma samples show the power of organoid technology. Cell Mol Life Sci. 2020 Nov 25.
13. Németh BC, Pesei ZG, Hegyi E, Szücs Á, Szentesi A, Hegyi P, Lowe ME, Sahin-Tóth M.: The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis. PLoS One. 2018 Nov 8;13(11):e0206869.
14. Osteikoetxea X, Benke M, Rodriguez M, Pálóczi K, Sódar BW, Szvicsek Z, Szabó-Taylor K, Vukman KV, Kittel Á, Wiener Z, Vékey K, Harsányi L, Szűcs Á, Turiák L, Buzás EI.: Detection and proteomic characterization of extracellular vesicles in human pancreatic juice. Biochem Biophys Res Commun. 2018 Apr 30;499(1):37-43.
15. Szücs Á, Marjai T, Szentesi A, Farkas N, Párniczky A, Nagy G, Kui B, Takács T, Czakó L, Szepes Z, Németh BC, Vincze Á, Pár G, Szabó I, Sarlós P, Illés A, Gódi S, Izbéki F, Gervain J, Halász A, Farkas G, Leindler L, Kelemen D, Papp R, Szmola R, Varga M, Hamvas J, Novák J, Bod B, Sahin-Tóth M, Hegyi P; Hungarian Pancreatic Study Group.: Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group. PLoS One. 2017 Feb 16;12(2):e0171420.
16. Huszár O, Kokas B, Mátrai P, Hegyi P, Pétervári E, Vincze Á, Pár G, Sarlós P, Bajor J, Czimmer J, Mosztbacher D, Márta K, Zsiborás C, Varjú P, Szücs Á.: Meta-Analysis of the Long Term Success Rate of Different Interventions in Benign Biliary Strictures. PLoS One. 2017 Jan 11;12(1):e0169618.
17. Párniczky A, Kui B, Szentesi A, Balázs A, Szűcs Á, Mosztbacher D, Czimmer J, Sarlós P, Bajor J, Gódi S, Vincze Á, Illés A, Szabó I, Pár G, Takács T, Czakó L, Szepes Z, Rakonczay Z, Izbéki F, Gervain J, Halász A, Novák J, Crai S, Hritz I, Góg C, Sümegi J, Golovics P, Varga M, Bod B, Hamvas J, Varga-Müller M, Papp Z, Sahin-Tóth M, Hegyi P; Hungarian Pancreatic Study Group.: Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. PLoS One. 2016 Oct 31;11(10):e0165309.

Officers:
President:  Prof. Attila Szijarto MD DSc 

Board Members:

Prof. Attila Olah MD DSc 
Akos Szucs MD PhD 
Oszkar Hahn MD PhD 
Andras Fulop MD PhD 
Andras Papp MD PhD 
Karoly Kalmar Nagy MD 
Kristof Dede MD PhD 

Members: under process

Contact/Secretariat:
Prof. Attila Szijarto MD DSc
Semmelweis University, 1st Department of Surgery and Interventional Gastroenterology Üllöi út 78, Budapest, H-1082 Hungary
Telephone: +36-20-825-89-25
Email: szijarto.attila@med.semmelweis-univ.hu
Website: https://semmelweis.hu/sebeszet1/